Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.3
USERS' SCORE
Moderately Good
Based on 31 Reviews
7.9
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin D-3 (as Cholecalciferol)
25 mcg (1,000 IU)
125%
Calcium (from Aquamin® TG Seaweed Derived Minerals and Calcium Citrate)
400 mg
31%
Magnesium (from Magnesium Oxide, Magnesium Glycinate, Magnesium Taurinate, Magnesium Citrate and Aquamin® TG Seaweed Derived Minerals)
800 mg
190%
Zinc (from L-OptiZinc® Monomethionine)
15 mg
136%
Top Medical Research Studies
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
7
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
Most Useful Reviews
9
Pain relief achieved
284 people found this helpful
While breastfeeding, I often experienced bone pain. After taking these supplements for two weeks, the pain subsided. Additionally, my nails have become significantly stronger.
Read More
9
Improved bone health
100 people found this helpful
Excellent! The combination of magnesium and calcium is remarkable for enhancing bone health. They significantly promote calcium absorption in the body, resulting in stronger bones, which consequently reduces the likelihood of sustaining bone injuries. I take it for preventive measures and strongly recommend it!
Read More
9
Energy boost noticed
6 people found this helpful
Miracle-complex - my nails are now incredibly strong! Magnesium and calcium work well together, supporting heart and nervous system functions. After two weeks of taking two tablets daily, I felt much calmer, more energetic, and noticed rapid nail growth. I experienced no adverse effects, and overall the supplement had a very positive impact on my health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.3
- All Researches
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
7
Promising drug delivery for osteoporosis
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
7
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 31 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Pain relief achieved
284 people found this helpful
While breastfeeding, I often experienced bone pain. After taking these supplements for two weeks, the pain subsided. Additionally, my nails have become significantly stronger.
Read More
9
Improved bone health
100 people found this helpful
Excellent! The combination of magnesium and calcium is remarkable for enhancing bone health. They significantly promote calcium absorption in the body, resulting in stronger bones, which consequently reduces the likelihood of sustaining bone injuries. I take it for preventive measures and strongly recommend it!
Read More
9
Energy boost noticed
6 people found this helpful
Miracle-complex - my nails are now incredibly strong! Magnesium and calcium work well together, supporting heart and nervous system functions. After two weeks of taking two tablets daily, I felt much calmer, more energetic, and noticed rapid nail growth. I experienced no adverse effects, and overall the supplement had a very positive impact on my health.
Read More
10
Strong bones
5 people found this helpful
Pregnant women take note! I highly recommend taking this supplement during pregnancy. After using it from my second trimester, I noticed significant improvements. My teeth and hair became healthier, and the muscle cramps disappeared, leading to a healthy delivery of my children. I truly believe in the effectiveness of this product!
Read More
9
Fracture recovery aided
5 people found this helpful
This calcium supplement significantly aided my recovery from fractures. I selected it for its optimal magnesium and calcium ratio. The chelated form of these minerals is particularly important for absorption. It also contains vitamin D and zinc for strengthening bones, making it an excellent choice for my recovery.
Read More
Frequently Asked Questions
9
Pain relief achieved
284 people found this helpful
While breastfeeding, I often experienced bone pain. After taking these supplements for two weeks, the pain subsided. Additionally, my nails have become significantly stronger.
9
Improved wellbeing
1 people found this helpful
I appreciated that this Calcium and Magnesium complex includes calcium, zinc, and vitamin D3 for optimal calcium absorption. Each element plays a vital role in strengthening bones, teeth, and overall health. After about a month of my daughter taking this, her nighttime cramps and leg numbness ceased. It’s undoubtedly effective.
7.5
Pain relief
5 people found this helpful
My husband suffers from calcium deficiency and experiences bone pain in his arms. After taking calcium with magnesium for a month, we observed improvement. His sleep has returned to normal, and we're pleased with the product's quality.
9
Less joint pain
5 people found this helpful
An excellent complex featuring magnesium, calcium, and vitamin D3. This combination works well for me, significantly improving my muscle cramps and weaknesses. I’ve been taking two pills a day for a few months, and my joints ache much less now.
7.5
Cramps resolved
161 people found this helpful
I appreciated the Calcium and Magnesium complex for its inclusion of essential nutrients like zinc and vitamin D to improve calcium absorption. After a month of taking this, my daughter experienced relief from night muscle cramps and numbness in her legs, confirming that this product is effective.
7
Joint problems eased
5 people found this helpful
Convenient formula! After a couple of weeks, I noticed remarkable benefits from this vitamin complex. I am no longer troubled by calf cramps at night, and my mood, sleep, and overall well-being have improved. Although the supplements didn't entirely fix my joint deformities, they did strengthen my bones and reduce the clicking noise in my joints, which has been very beneficial.
9
Supports restful sleep
4 people found this helpful
I highly recommend this! Calcium strengthens bones, teeth, hair, and nails, while magnesium enhances sleep quality. Better sleep results in increased energy levels, and added zinc and vitamin D help with calcium absorption.
9
Energy boost noticed
6 people found this helpful
Miracle-complex - my nails are now incredibly strong! Magnesium and calcium work well together, supporting heart and nervous system functions. After two weeks of taking two tablets daily, I felt much calmer, more energetic, and noticed rapid nail growth. I experienced no adverse effects, and overall the supplement had a very positive impact on my health.
7.5
Bone pain improvement
1 people found this helpful
Good quality magnesium and calcium! I primarily take it for my father, who has had trouble sleeping after a major operation. Following the doctor's advice for three tablets at night, he now sleeps well, feels calmer, and his bone pain has lessened.
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
References
- von Brackel FN, Grambeck J, Barvencik F, Amling M, Oheim R. In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution. JBMR Plus. 2024;8:ziae139. 10.1093/jbmrpl/ziae139
- Alsaikhan F, Mahmoud MZ, Suliman M. Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis. Front Bioeng Biotechnol. 2023;11:1153969. 10.3389/fbioe.2023.1153969
- Jakubowska-Pietkiewicz E, Chlebna-Sokół D. New trends in the treatment of osteogenesis imperfecta type III - own experience. Ortop Traumatol Rehabil. 2008;10:593.
- Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129.
